反应 #607474

反应方程式

4,4′-trimethylene dipiperidine bispropanoic acid bis-boc-1,3-diamino propane

HCl

→

product

收率 122.7%

4,4′-trimethylene dipiperidine bispropanoic acid 1,3-diamino propane

收率 122.7%

溶剂

methanol

反应条件

后处理

1. 1
   其他After removal of the solvent under reduced pressure
2. 2
   workup.DISSOLUTIONthe residue was dissolved in 10 mL of methanol/water (1:1)
3. 3
   workup.ADDITIONwas treated with 5 g of Amberlyst OH 26 resin
4. 4
   workup.STIRRINGAfter stirring at room temperature for 3 hours
5. 5
   过滤the resin was filtered off
6. 6
   其他The filtrate was evaporated dryness

实验过程

To 0.55 g of 4,4′-trimethylene dipiperidine bispropanoic acid-bis-boc-1,3-diamino propane dissolved in 5 mL of methanol was added 0.5 mL of concentrated HCl and the reaction mixture was stirred at 50° C. for 10 hours. After removal of the solvent under reduced pressure, the residue was dissolved in 10 mL of methanol/water (1:1) and was treated with 5 g of Amberlyst OH 26 resin. After stirring at room temperature for 3 hours, the resin was filtered off. The filtrate was evaporated dryness and the residue was lyophilized yielding 0.5 g of the product as a white solid.

来源