反应 #607458

ord-1df9c2a8030f4e2683f6d2d94be875ff

反应方程式

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine

反应物

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
Apomorphine hydrochloride
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine hydrochloride

试剂

无

溶剂

O
water

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    workup.ADDITIONmixed thoroughly (i.e.
  2. 2
    workup.STIRRINGthe mixture was again homogenized
  3. 3
    workup.ADDITIONby addition of a suitable acid
  4. 4
    workup.ADDITIONThe solution is then poured onto a sheet
  5. 5
    其他dried in a heated oven

实验过程

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09326981B2uspto-grants-2016_05