反应 #60715

反应方程式

3-chloro-N-[1-(4-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

paraformaldehyde

→

3-Chloro-N-[1-(4-fluorophenyl)-2-(1-methylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide

反应条件

后处理

1. 1
   其他afforded
2. 2
   其他after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 115 mg (30%) of the title compound

实验过程

Using alkylation method B, 3-chloro-N-[1-(4-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (373 mg, 0.87 mmol) and paraformaldehyde (520 mg, 17 mmol) afforded, after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 115 mg (30%) of the title compound.

来源