反应 #60542

反应方程式

4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester

→

title compound

收率 99.5%

4-(5-Fluoro-2-methoxyphenyl)piperidine-1-carboxylic acid t-butyl ester

收率 99.5%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered through Celite
2. 2
   浓缩the obtained filtrate was concentrated under reduced pressure

实验过程

To a solution of 4-(5-fluoro-2-methoxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid t-butyl ester (2.0 g, 6.5 mmol) produced in Example (106a) in methanol (30 mL) was added 10% palladium on carbon (0.99 g, wet), the mixture was stirred for 17 hours at atmospheric pressure and room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the obtained filtrate was concentrated under reduced pressure to give 2.0 g of the title compound as a light yellow oil.

来源