反应 #6035

反应方程式

potassium tert-butoxide

tetrahydrofuran

methyl isothiocyanate

tetrahydrofuran

2-(4-chlorophenyl)-5-phenylvaleronitrile

tetrahydrofuran

→

N-methyl-2-(4-chlorophenyl)-2-cyano-5-phenylthiovaleroamide

收率 52.6%

溶剂

Water

反应条件

后处理

1. 1
   workup.ADDITIONwas added to the mixture
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 2 hours
3. 3
   萃取the mixture was extracted with ethyl acetate
4. 4
   其他dried
5. 5
   其他condensed under reduced pressure
6. 6
   其他purified by silica gel chromatography

实验过程

To a tetrahydrofuran solution containing 1.78 g (6.6 mmole) of 2-(4-chlorophenyl)-5-phenylvaleronitrile was added a tetrahydrofuran solution containing 0.77 g (6.9 mmole) of potassium tert-butoxide at 0° C. After stirring for 30 minutes, a tetrahydrofuran solution containing 0.5 g (6.8 mmol) of methyl isothiocyanate was added to the mixture and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, dried and condensed under reduced pressure, and then purified by silica gel chromatography to obtain 1.19 g (yield: 52.4 %) of N-methyl-2-(4-chlorophenyl)-2-cyano-5-phenylthiovaleroamide as a crystal.

来源