反应 #60223

反应方程式

N-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]acetamide

Lawesson's reagent

→

1-{[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]amino}ethane-1-thione

溶剂

DME

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONdiluted with water and ethyl acetate
3. 3
   萃取The solution was extracted three times with ethyl acetate
4. 4
   干燥dried over sodium sulfate
5. 5
   其他purified by column chromatography
6. 6
   洗涤eluting with 5-10% methanol/methylene chloride

实验过程

1 mmol of N-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]acetamide and 2 mmol of Lawesson's reagent were stirred in 2 ml of DME at 80° C. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate, dried over sodium sulfate, and purified by column chromatography eluting with 5-10% methanol/methylene chloride.

来源