反应 #598942

反应方程式

acetonitrile

4-aminothiophenol

triethylamine

1-iodoheptafluoro-n-propane

→

title compound

收率 63.2%

4-(heptafluoro-n-propylthio)aniline

收率 63.2%

溶剂

ether

反应条件

后处理

1. 1
   洗涤washed with a 1N sodium hydroxide aqueous solution
2. 2
   其他Then, the product was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=4:1)

实验过程

To an acetonitrile solution (20 ml) of 4-aminothiophenol (1.25 g, 9.98 mmol) and triethylamine (1.11 g, 11.0 mmol) was added 1-iodoheptafluoro-n-propane (5.91 g, 19.9 mmol), and the resultant mixture was stirred at room temperature for 3 hours. The mixture was diluted with ether, and washed with a 1N sodium hydroxide aqueous solution. Then, the product was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=4:1) to obtain 1.85 g (yield 63%) of the title compound.

来源