反应 #5975

反应方程式

methyl 2-methoxy-4-acetylamino-5-chlorobenzoate

BBr3

sodium hydroxide

→

4-acetylamino-5-chlorosalicylic acid

溶剂

methylene chloride

methylene chloride

反应条件

后处理

1. 1
   workup.DISSOLUTIONis dissolved
2. 2
   其他The two layers are separated
3. 3
   过滤filtered
4. 4
   洗涤washed with water
5. 5
   其他evaporated to dryness

实验过程

To a mixture of 16 g of methyl 2-methoxy-4-acetylamino-5-chlorobenzoate in 130 ml of methylene chloride is slowly added 100 ml of a methylene chloride solution of borontribromide (250 g BBr3 per liter) and stirring continued for 24 hours. 1N sodium hydroxide solution is then added until all material is dissolved. The two layers are separated and the aqueous layer is acidified with 1N hydrochloric acid, filtered, washed with water and evaporated to dryness to give 4-acetylamino-5-chlorosalicylic acid which is used directly in the next step.

来源