反应 #59636
ord-2870f34e8b1c47c59fdc29725e9d888c
反应方程式
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1其他This compound is prepared
- 2温度the mixture is then refluxed for 30 minutes
- 3萃取it is extracted with EtOAc
- 4干燥the organic phase is dried over Na2SO4
- 5其他the solvent is evaporated off under vacuum
- 6其他the precipitate formed
- 7过滤is spin-filtered off
实验过程
This compound is prepared according to the process described in Organic Syntheses, 1925, V, 71-74. A solution of 16.5 ml of concentrated HCl in 120 ml of water and a solution of 41.5 g of hydroxylamine hydrochloride in 70 ml of water are added to a mixture of 25 g of 5-aminoindane, 35 g of chloral hydrate and 22 g of Na2SO4 in 600 ml of water, and the mixture is then refluxed for 30 minutes. After cooling the reaction mixture to RT, it is extracted with EtOAc, the organic phase is dried over Na2SO4 and the solvent is evaporated off under vacuum. The residue is taken up in a pentane/iso ether mixture and the precipitate formed is spin-filtered off. 23 g of the expected product are obtained.