反应 #595376

反应方程式

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

收率 97.4%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   浓缩After completion the reaction mixture was concentrated under reduced pressure
2. 2
   其他the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

实验过程

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

来源