反应 #595353

反应方程式

compound

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

thionyl chloride

→

Methyl 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole-5-carboxylate

反应条件

后处理

1. 1
   其他The excess thionyl chloride is removed under reduced pressure
2. 2
   洗涤The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   干燥The organic phase is dried over magnesium sulfate
4. 4
   其他the solvent is removed under reduced pressure
5. 5
   其他The product obtained
6. 6
   其他is used without further purification in the subsequent reactions

实验过程

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

来源