反应 #595352

反应方程式

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

溶剂

methanol

water

反应条件

后处理

1. 1
   萃取extracted three times with in each case 10 ml of diethyl ether
2. 2
   干燥The combined organic phases are dried over magnesium sulfate
3. 3
   其他the solvent is removed on a rotary evaporator
4. 4
   其他The product obtained
5. 5
   其他is used without further purification in the subsequent reaction

实验过程

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

来源