反应 #595351

反应方程式

compound

2-(4-Chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylic acid

trimethylsilyldiazomethane

→

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

溶剂

toluene

hexane

methanol

反应条件

后处理

1. 1
   其他the solvent is then removed on a rotary evaporator
2. 2
   其他The residue is used without further purification in the subsequent reaction

实验过程

138 mg (0.52 mmol) of the compound from Example 42A are dissolved in 3 ml toluene and 2.5 ml of methanol. 0.4 ml (0.79 mmol) of a 2 M solution of trimethylsilyldiazomethane in hexane is then added dropwise. The mixture is stirred at RT for 10 min and the solvent is then removed on a rotary evaporator. The residue is used without further purification in the subsequent reaction.

来源