反应 #595347

反应方程式

compound

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

反应条件

后处理

1. 1
   其他excess thionyl chloride is then removed under reduced pressure
2. 2
   洗涤washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   干燥The organic phase is dried over magnesium sulfate
4. 4
   其他the solvent is removed on a rotary evaporator
5. 5
   其他The product obtained
6. 6
   其他is used without further purification in the subsequent reactions

实验过程

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

来源