反应 #595343

反应方程式

compound

2-(4-Chlorophenyl)-5-ethyl-4-methyl-1,3-oxazole 3-oxide

phosphoryl chloride

ammonia

→

4-(Chloromethyl)-2-(4-chlorophenyl)-5-ethyl-1,3-oxazole

溶剂

chloroform

反应条件

后处理

1. 1
   温度The mixture is heated
2. 2
   温度to reflux
3. 3
   萃取The reaction mixture is extracted three times with in each case 20 ml of ethyl acetate
4. 4
   其他The solvent is removed on a rotary evaporator
5. 5
   其他the residue is dried in a vacuum
6. 6
   其他drying cabinet
7. 7
   其他The product is used without further purification in the subsequent reactions

实验过程

1.00 g (4.21 mmol) of the compound from Example 29A are dissolved in 15 ml of chloroform, and 1.4 ml (15.15 mmol) of phosphoryl chloride are added carefully. The mixture is heated to reflux and stirred at this temperature for 30 min. The mixture is then cooled to 0° C. and made slightly basic using ammonia. The reaction mixture is extracted three times with in each case 20 ml of ethyl acetate. The solvent is removed on a rotary evaporator and the residue is dried in a vacuum drying cabinet. The product is used without further purification in the subsequent reactions.

来源