反应 #595341

反应方程式

compound

[2-(4-Chloro-3-methylphenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-2-(4-chloro-3-methylphenyl)-1,3-oxazole

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他The solvent is then removed on a rotary evaporator
2. 2
   其他The residue is used without further purification in the subsequent reactions

实验过程

136 mg (0.61 mmol) of the compound from Example 27A are suspended in 2 ml of dichloromethane. The suspension is cooled to 0° C., and 49 μl (0.67 mmol) of thionyl chloride are added slowly. The reaction solution is stirred at RT overnight. The solvent is then removed on a rotary evaporator. The residue is used without further purification in the subsequent reactions.

来源