反应 #595335

反应方程式

4-fluoro-3-methylbenzamide

1,3-dichloro-acetone

sulfuric acid

→

4-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

溶剂

反应条件

后处理

1. 1
   其他A melt is formed
2. 2
   workup.STIRRINGstirred at RT overnight
3. 3
   其他The precipitate formed
4. 4
   过滤is filtered off
5. 5
   其他dried at 40° C. in a vacuum
6. 6
   其他drying cabinet overnight

实验过程

2.00 g (12.80 mmol) of 4-fluoro-3-methylbenzamide and 1.79 g (14.08 mmol) of 1,3-dichloro-acetone are stirred at 130° C. for 2 days. A melt is formed. The mixture is then cooled to RT, 3.0 ml of conc. sulfuric acid are added carefully at this temperature and the mixture is stirred for 15 min. The resulting suspension is poured into 20 ml of ice-water and stirred at RT overnight. The precipitate formed is filtered off and dried at 40° C. in a vacuum drying cabinet overnight.

来源