反应 #595333

反应方程式

3-fluoro-4-hydroxybenzaldehyde

2-bromoethanol

potassium carbonate

→

3-Fluoro-4-(2-hydroxyethoxy)benzaldehyde

溶剂

DMF

反应条件

后处理

1. 1
   过滤The mixture is then filtered
2. 2
   其他the filtrate is freed from the solvent on a rotary evaporator
3. 3
   workup.ADDITION20 ml of sat. aqueous sodium bicarbonate solution are added
4. 4
   其他The phases are separated
5. 5
   干燥the organic phase is dried over magnesium sulfate
6. 6
   其他The solvent is removed on a rotary evaporator
7. 7
   其他The product obtained
8. 8
   其他is used without further purification in the subsequent reaction

实验过程

5.00 g (35.69 mmol) of 3-fluoro-4-hydroxybenzaldehyde are dissolved in 50 ml of dry DMF. 5.35 g (42.82 mmol) of 2-bromoethanol and 19.73 g (142.74 mmol) of potassium carbonate are added. The reaction mixture is stirred at 150° C. for 10 h. The mixture is then filtered, and the filtrate is freed from the solvent on a rotary evaporator. The residue is taken up in 30 ml of ethyl acetate, and 20 ml of sat. aqueous sodium bicarbonate solution are added. The phases are separated and the organic phase is dried over magnesium sulfate. The solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

来源