反应 #595321

反应方程式

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

收率 71.0%

Butyl cyclopropanesulfonate

收率 71.0%

反应条件

后处理

1. 1
   温度The mixture was slowly warmed at room temperature
2. 2
   其他The solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   洗涤The organic phase was washed with water, brine
5. 5
   干燥dried (MgSO4)
6. 6
   浓缩concentrated

实验过程

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

来源