反应 #595181

反应方程式

sodium sulfate decahydrate

methyl 4-[((3-methylbutyl){4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}amino)methyl]benzoate

diisobutylaluminum hydride toluene

→

title compound

收率 75.4%

{4-[((3-methylbutyl){4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}amino)methyl]phenyl}methanol

收率 75.4%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度cooling
2. 2
   workup.STIRRINGthe mixture was further stirred at room temperature for 1 hr
3. 3
   过滤The insoluble material was filtered off
4. 4
   浓缩the filtrate was concentrated
5. 5
   其他The residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90-60/40)

实验过程

To a solution of methyl 4-[((3-methylbutyl){4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}amino)methyl]benzoate (1.34 g, 2.90 mmol) in tetrahydrofuran (10 mL) was added dropwise 1.0 M diisobutylaluminum hydride toluene solution (6.38 mL, 6.38 mmol) under ice-cooling. The reaction mixture was stirred at room temperature for 2 hr, sodium sulfate decahydrate was added and the mixture was further stirred at room temperature for 1 hr. The insoluble material was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90-60/40) to give the title compound (950 mg, yield 75%) as a colorless oil.

来源