反应 #593645

反应方程式

6-Amino-5-bromo-2-(4-chloro-2-fluoro-3-methoxyphenyl)-pyrimidine-4-carboxylic acid methyl ester

trimethyl((tributylstannyl)ethynyl)silane

→

title compound

收率 79.4%

6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-trimethylsilanylethynylpyrimidine-4-carboxylic acid methyl ester

收率 79.4%

溶剂

1,2-dichloroethane

反应条件

后处理

1. 1
   其他The cooled reaction mixture
2. 2
   浓缩was concentrated under vacuum
3. 3
   其他then purified by flash chromatography on silica gel (dichloromethane/ethyl acetate gradient)
4. 4
   其他A second purification by flash chromatography on silica gel (hexane/ethyl acetate gradient)

实验过程

6-Amino-5-bromo-2-(4-chloro-2-fluoro-3-methoxyphenyl)-pyrimidine-4-carboxylic acid methyl ester (1.0 g, 2.56 mmol), trimethyl((tributylstannyl)ethynyl)silane (1.98 g, 5.12 mmol), and bis(triphenylphosphine)palladium(II) dichloride (0.18 g, 0.256 mmol) were combined in 1,2-dichloroethane (10 mL) and heated in a CEM microwave reactor at 110° C. for 15 min. The cooled reaction mixture was concentrated under vacuum then purified by flash chromatography on silica gel (dichloromethane/ethyl acetate gradient). A second purification by flash chromatography on silica gel (hexane/ethyl acetate gradient) yielded the title compound (0.829 g, 79% yield): mp 126-128° C.

来源