反应 #592673

反应方程式

Intermediate 3B

(2S)-2-Amino-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid methyl ester

α-fluorocinnamic acid

→

(2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-2-(2-fluoro-3-phenyl-acryloylamino)-propionic acid

收率 28.0%

反应条件

实验过程

Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and α-fluorocinnamic acid was used in place of cinnamic acid to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-2-(2-fluoro-3-phenyl-acryloylamino)-propionic acid as a white solid with the yield of 28% and mp: 243˜245° C.

来源