反应 #5883

反应方程式

thiophosgene

6-amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole

potassium bicarbonate

→

2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole

溶剂

chloroform

chloroform

chloroform

反应条件

后处理

1. 1
   温度maintaining the temperature at 0°-2°
2. 2
   过滤The solid is filtered
3. 3
   其他the filtrate is evaporated
4. 4
   其他The solid thus obtained
5. 5
   过滤filtered through a silica gel column
6. 6
   其他The filtrate is evaporated

实验过程

To a cooled mixture of 2.1 g of 6-amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole and 2.8 g of potassium bicarbonate in 20 ml of chloroform is added dropwise 1.6 g of thiophosgene in 5 ml of chloroform under stirring. The stirring is continued for 2 hours maintaining the temperature at 0°-2° . The solid is filtered and the filtrate is evaporated. The solid thus obtained is dissolved in chloroform and filtered through a silica gel column. The filtrate is evaporated to give 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 54°-58°.

来源