反应 #586175

反应方程式

NaHCO3

Methyl (7R)-7-[(tert-butoxycarbonyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

TFA

→

product

收率 100.0%

methyl (7R)-7-amino-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

收率 100.0%

溶剂

DCM

DCM

反应条件

后处理

1. 1
   其他before separating the phases
2. 2
   萃取extracting the aqueous with DCM
3. 3
   洗涤The combined organics were washed with brine
4. 4
   干燥dried over Na2SO4
5. 5
   过滤filtered
6. 6
   浓缩concentrated in vacuo

实验过程

Methyl (7R)-7-[(tert-butoxycarbonyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.14 M) in DCM was treated with TFA (10 eq) and stirred at RT for 1 h. The reaction was diluted with DCM and cautiously basified with aq. NaHCO3, before separating the phases and extracting the aqueous with DCM. The combined organics were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to afford the product as an off-white foam (100%) that was used without further purification. (ES+) m/z 405 (M+H)+; [α]D+42.3, c=1, MeOH

来源