反应 #586172

反应方程式

Cs2CO3

4-(aminosulfonyl)butanoic acid

benzyl bromide

→

title compound

收率 27.0%

benzyl 4-(aminosulfonyl)butanoate

收率 27.0%

溶剂

DMF

DCM

反应条件

后处理

1. 1
   workup.WAITthe reaction left
2. 2
   过滤filtering
3. 3
   浓缩The filtered liquor was concentrated in vacuo
4. 4
   洗涤washed with saturated aqueous NaHCO3, water and brine
5. 5
   干燥before being dried over Na2SO4
6. 6
   过滤filtered
7. 7
   浓缩concentrated in vacuo

实验过程

Cs2CO3 (0.51 eq) was added to a solution of 4-(aminosulfonyl)butanoic acid (1 M) in DMF. After 1 h, benzyl bromide (1 eq) was introduced and the reaction left to stir overnight before diluting with DCM and filtering. The filtered liquor was concentrated in vacuo, the residue taken up in DCM and washed with saturated aqueous NaHCO3, water and brine, before being dried over Na2SO4, filtered and concentrated in vacuo. Trituration of the residue with Et2O afforded the title compound as a white solid (27%). (ES+) m/z 280 (M+Na)+

来源