反应 #586168

反应方程式

water

2,3-dihydro-7,8-dimethoxy-5-hydroxy-2-oxo-1H-[1]-benzazepine-4-carboxylic acid ethyl ester

water

→

title compound

收率 72.7%

7,8-Dimethoxy-1H-benzazepine-2,5 (3H, 4H)-dione

收率 72.7%

溶剂

dimethylsulfoxide

反应条件

后处理

1. 1
   温度heating
2. 2
   温度the mixture was cooled to 20° C.
3. 3
   workup.WAITto stand overnight at 4° C
4. 4
   过滤The crystals were filtered off
5. 5
   洗涤washed with water and hexanes

实验过程

A solution of 2,3-dihydro-7,8-dimethoxy-5-hydroxy-2-oxo-1H-[1]-benzazepine-4-carboxylic acid ethyl ester (0.614 g, 1.9 mmol) and water (1 ml) in dimethylsulfoxide (20 ml) was stirred at 150° C. under argon. Portions of water (1 ml) were added after 1 hour and 3 hours heating. After stirring for a total of 6 hours at 150° C., the mixture was cooled to 20° C., poured into ice cold water (20 ml) and allowed to stand overnight at 4° C. The crystals were filtered off and washed with water and hexanes to give the title compound as yellowish crystals (0.325 g, yield 67.7%), mp 230° C.; 1H-NMR (DMSO-d6, 300 MHz): δ (ppm)=8.42 (s; 1H), 7.5 (s; 1H), 6.43 (s; 1H), 3.96 and 3.92 (s; 6H), 2.90 (m, 2H), 2.8 (m; 2H).

来源