反应 #586161

反应方程式

neohesperidin

Neohesperidin

dihydrochalcone

→

1-(2,4,6-trihydroxyphenyl)-3-(3′-hydroxy-4′-methoxyphenyl)-1-propanol

溶剂

HCl

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate (3×10 ml)
2. 2
   其他evaporated
3. 3
   其他to remove ethyl acetate
4. 4
   workup.DISSOLUTIONdissolved in 1-propanol (5 ml)
5. 5
   workup.ADDITIONSodium borohydride (25 mg) was added to the propanol solution
6. 6
   其他After the completion of the reaction
7. 7
   其他the mixture was separated on a pre-packed C18 column
8. 8
   洗涤eluting with a MeOH/H2O gradient

实验过程

Neohesperidin is a glycoside of dihydrochalcone. A total weight of 100 mg of neohesperidin was suspended in 10 ml of 1N HCl and heated at 80° C. for 2 hours. The hydrolyzed product (10) was cooled down and extracted with ethyl acetate (3×10 ml). The ethyl acetate layers were combined, evaporated to remove ethyl acetate and dissolved in 1-propanol (5 ml). Sodium borohydride (25 mg) was added to the propanol solution and stirred at room temperature for 2 hours. After the completion of the reaction, the mixture was separated on a pre-packed C18 column eluting with a MeOH/H2O gradient to provide 1-(2,4,6-trihydroxyphenyl)-3-(3′-hydroxy-4′-methoxyphenyl)-1-propanol (11).

来源