反应 #586160

反应方程式

sodium borohydride

sodium borohydride

1,3-Bis(2,4-dimethoxyphenyl)-propan-1,3-dione

acetic acid

→

1,3-bis(2,4-dimethoxyphenyl)-propan-1,3-diol

1,3-Bis(2,4-dimethoxyphenyl)-propan-1,3-diol

溶剂

1-propanol

反应条件

后处理

1. 1
   其他to react at room temperature for 3 hours
2. 2
   workup.ADDITIONwas added
3. 3
   其他The mixture was then separated on a pre-packed C18 column
4. 4
   洗涤eluting with a MeOH/H2O gradient

实验过程

1,3-Bis(2,4-dimethoxyphenyl)-propan-1,3-dione (8) (5 mg) was dissolved in 1-propanol (1 ml), followed by the addition of sodium borohydride (3 mg) and the mixture was allowed to react at room temperature for 3 hours. Upon completion of the reaction, 20% acetic acid (0.2 ml) was added to neutralize the excess sodium borohydride. The mixture was then separated on a pre-packed C18 column eluting with a MeOH/H2O gradient to provide 1,3-bis(2,4-dimethoxyphenyl)-propan-1,3-diol (9).

来源