反应 #586153

反应方程式

2,4-dichlorophenylboronic acid

4-bromo-2-fluorobenzonitrile

sodium carbonate

toluene

→

2-fluoro-4-(2,4-dichlorophenyl)benzonitrile

收率 94.0%

溶剂

water

ethanol

反应条件

后处理

1. 1
   温度under reflux
2. 2
   温度with heating for 2 hours
3. 3
   workup.ADDITIONThe reaction mixture was poured into ice-cold water
4. 4
   萃取extracted with toluene
5. 5
   洗涤The toluene layer was washed with water twice
6. 6
   干燥dried over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

实验过程

1.0 g (5.2 mmol) of 2,4-dichlorophenylboronic acid, 1.1 g (5.5 mmol) of 4-bromo-2-fluorobenzonitrile, 1.6 g (15.0 mmol) of sodium carbonate and 0.8 g (0.7 mmol) of tetrakis(triphenylphosphine) palladium were added to a solvent mixture of 50 ml of toluene, 25 ml of ethanol and 25 ml of water, and the reaction was carried out under reflux with heating for 2 hours. The reaction mixture was poured into ice-cold water and extracted with toluene. The toluene layer was washed with water twice and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 1.3 g of 2-fluoro-4-(2,4-dichlorophenyl)benzonitrile (yield 93.0%), which was used in Example 8 (1) as the starting material.

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