反应 #586113

反应方程式

N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide

→

N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide

收率 85.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他In a flask equipped with a magnetic stirring bar
2. 2
   其他Nitrogen is bubbled through the solution and 10% Pd on charcoal
3. 3
   workup.ADDITIONis added
4. 4
   其他After flushing with nitrogen
5. 5
   其他The suspension is flushed with nitrogen
6. 6
   过滤filtered
7. 7
   洗涤rinsed over Celite
8. 8
   浓缩The filtrate is concentrated under vacuum

实验过程

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide (85%).

来源