反应 #586102

反应方程式

N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide

potassium hydroxide

methanol

→

3-(1,1-dimethypropyl)-2-methyl-phenylamine

溶剂

water

反应条件

后处理

1. 1
   温度at reflux temperature for 15 hours
2. 2
   workup.ADDITIONis added
3. 3
   萃取the reaction mixture is extracted with ethylacetate
4. 4
   干燥After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum
5. 5
   其他the product is purified by destillation (bp. ca. 70° C., 13,33 Pa)

实验过程

2,21 g (10.77 mmol) N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide, 1,42 g (21.54 mmol) 85% potassium hydroxide and 9 ml methanol are heated under stirring at reflux temperature for 15 hours. After cooling 100 ml of water is added and the reaction mixture is extracted with ethylacetate. After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum, the product is purified by destillation (bp. ca. 70° C., 13,33 Pa). This gives 1.7 g of 2-Methyl-3-(1,1-dimethylpropyl)phenylamine in the form of a colourless oil (89% of theory).

来源