反应 #586100

反应方程式

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

收率 88.0%

溶剂

tetrahydrofurane

反应条件

后处理

1. 1
   过滤The catalyst was filtered off
2. 2
   其他after evaporation of the solvent
3. 3
   其他the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

实验过程

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

来源