反应 #586086

反应方程式

pyrrolidine

chloroacetyl chloride

→

N-(2-chloroacetyl)pyrrolidine

收率 85.4%

溶剂

dichloromethane

反应条件

后处理

1. 1
   洗涤The organic phase was washed with solutions of sodium hydrogen sulphate and sodium carbonate
2. 2
   其他dried
3. 3
   其他After evaporation of the solvent

实验过程

3.82 moles of pyrrolidine were added to a solution of 1.92 moles of chloroacetyl chloride in 600 ml of dichloromethane. The temperature was maintained at 0° C. The organic phase was washed with solutions of sodium hydrogen sulphate and sodium carbonate and dried. After evaporation of the solvent, 242 g of N-(2-chloroacetyl)pyrrolidine were obtained. 1.64 moles of this compound were dissolved in 500 ml of toluene and 231 ml of triethylamine were added. This was heated under reflux for 3 hrs and after cooling 311.5 g of product were isolated in the form of a precipitate. 119.07 g of the product obtained were dissolved in

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