反应 #582497

反应方程式

(2S, 3R)-2-amino-3-octadecanol

1,1′-carbonyldiimidazole

triethylamine

→

(4S, 5R)-4-Methyl-5-(n-pentadecyl)-oxazolidinone

溶剂

dichloromethane

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   其他the solvent removed by a stream of nitrogen
3. 3
   其他The crude product 158 was analyzed without purification

实验过程

(2S, 3R)-2-amino-3-octadecanol (155, 750 μg, 2.6 μmol) was dissolved in dichloromethane (100 μL) to which 1,1′-carbonyldiimidazole (0.85 mg, 5.3 μmol) and triethylamine (0.4 μL, 2.9 μmol) was added. The solution was stirred for 5 h and then the solvent removed by a stream of nitrogen. The crude product 158 was analyzed without purification: IR (NaCI) 36, 2919, 2851, 1742, 1713, 1551, 1470, 1395, 1321, 49, 1239, 1094, 1061, 1001, 768, 743, 664 cm−1; FABMS m/z 785, 623, 474, 406, 362, 328, 312, 286, 268.

来源