反应 #58179

反应方程式

6-phenyl-2-pyridin-4-yl-pyrimidin-4-ol

Intermediate 3

6-phenyl-2-pyridin-4-yl-pyrimidin-4-ol

methyl 4-(bromomethyl)benzoate

→

title compound

4-{[(6-Phenyl-2-pyridin-4-ylpyrimidin-4-yl)oxy]methyl}benzoic acid

反应条件

实验过程

The title compound was prepared from 6-phenyl-2-pyridin-4-yl-pyrimidin-4-ol (which was obtained in Intermediate 3) and methyl 4-(bromomethyl)benzoate according to Method A and Method B; 1H NMR (DMSO-d6, 300 MHz) δ 5.65 (s, 2H), 7.26 (t, J=8.8 Hz, 2H), 7.50-7.70 (m, 4H), 8.30-8.40 (m, 2H), 8.57 (d, J=4.9 Hz, 2H), 8.90 (d, J=4.9 Hz, 2H); LC retention time 2.79 min; MS: m/z (ESI) 382 (M−H).

来源