反应 #57820

反应方程式

(2-amino-5-chloro-phenyl)-(6-methyl-pyridin-3-yl)-methanone

4-bromo-3-fluoro-benzenesulfonyl chloride

→

title compound

4-Bromo-N -[4-chloro-2-(6-methyl-pyridine-3-carbonyl)-phenyl]-3-fluoro-benzenesulfonamide

溶剂

pyridine

反应条件

后处理

1. 1
   其他Purification on silica gel with flash column chromatography
2. 2
   其他gave a light orange solid

实验过程

The title compound was prepared according to the general procedures for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-amino-5-chloro-phenyl)-(6-methyl-pyridin-3-yl)-methanone 2.4 g (8.77 mmol) and 4-bromo-3-fluoro-benzenesulfonyl chloride 2.16 g (8.77 mmol) stirred in 14 ml pyridine. Purification on silica gel with flash column chromatography gave a light orange solid.

来源