反应 #57815

反应方程式

(2-amino-5-chloro-phenyl)-pyridin-3-yl-methanone

4-bromo-benzenesulfonyl chloride

→

title compound

4-Bromo-N-[4-chloro-2-(pyridine-3-carbonyl)-phenyl]-benzenesulfonamide

溶剂

pyridine

反应条件

后处理

1. 1
   其他overnight
2. 2
   其他at 80° C.
3. 3
   其他to yield a salmon color solid

实验过程

The title compound was prepared according to the general procedures for the synthesis of N-Aryl-benzenesulfonamides previously described using (2-amino-5-chloro-phenyl)-pyridin-3-yl-methanone 5 g (21.5 mmol) and 4-bromo-benzenesulfonyl chloride 5.78 g (21.5 mmol), in 150 ml anhydrous pyridine, overnight at 80° C., followed by flash column chromatography on silica gel to yield a salmon color solid.

来源