反应 #577172

反应方程式

1-Ethyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester

Lithium hydroxide monohydrate

→

1-Ethyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid

溶剂

MeOH H2O

反应条件

后处理

1. 1
   其他The mixture which resulted
2. 2
   温度was heated
3. 3
   温度to reflux overnight
4. 4
   其他The solvent was removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue was dissolved in H2O (500 mL)
6. 6
   过滤The solid was collected by filtration
7. 7
   其他dried under vacuum (4.0 g, 94.5%)

实验过程

1-Ethyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester (4.5 g, 9.37 mmol) was added to MeOH/H2O (110 mL, 10/1). Lithium hydroxide monohydrate (1.5 g, 35.7 mmol) was added to the above mixture. The mixture which resulted was heated to reflux overnight. The solvent was removed under reduced pressure and the residue was dissolved in H2O (500 mL). The solution was acidified with 6N HCl to pH 2. The solid was collected by filtration and dried under vacuum (4.0 g, 94.5%).

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