反应 #57560

反应方程式

4-bromoaniline

benzofuran-2-carboxylic acid chloride

triethylamine

→

N-(4-bromophenyl)-1-benzofuran-2-carboxamide

收率 82.6%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   温度cooled in ice bath
2. 2
   洗涤The dichloromethane layer was washed with water, 1N HCl, water and brine
3. 3
   干燥dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated in vacuo

实验过程

To 1.72 g of 4-bromoaniline was added to 1.89 g of benzofuran-2-carboxylic acid chloride in 35 mL of dichloromethane cooled in ice bath, followed by the addition of 4.9 mL of triethylamine. The reaction was stirred at room temperature overnight and then diluted with dichloromethane. The dichloromethane layer was washed with water, 1N HCl, water and brine, dried over Na2SO4, filtered, and concentrated in vacuo to provide 2.61 g of N-(4-bromophenyl)-1-benzofuran-2-carboxamide as a yellow solid. Yield 72%. m.p. 178-180° C.; MS: 314.1(M−H)−.

来源