反应 #5726

反应方程式

methoxymethylchloride

N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea

potassium hydroxide

methyl iodide

→

N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea

溶剂

dimethyl formamide

—

ice water

反应条件

后处理

1. 1
   其他The resulting reaction
2. 2
   其他the solid substance is isolated

实验过程

10.3 g of N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea and 1.88 g of powdered potassium hydroxide (90% are dissolved 40 ml of dimethyl formamide, after which 4.7 of methyl iodide are added drop by drop to the clear solution. The resulting reaction is exothermic. After stirring for two hours the solution is diluted with ice water and the solid substance is isolated. Yield 10.3 g. Melting point 124°-126° C. In a completely similar manner but using methoxymethylchloride instead of methyliodide, N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea is produced. Melting point 121.5°-122.5° C.

来源