反应 #571835

反应方程式

2-(4-methoxyphenyl)-1,3-dioxolane-2-methanamine hydrochloride

1-isothiocyanato-2-methylpropane

potassium carbonate

→

N-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-N'-(2-methylpropyl)thiourea

收率 89.7%

溶剂

2-propanol

反应条件

后处理

1. 1
   温度refluxed for 3 hours
2. 2
   过滤The reaction mixture is filtered while hot and the filtrate
3. 3
   其他is evaporated
4. 4
   其他The solid residue is crystallized from a mixture of benzene and petroleumether
5. 5
   过滤The product is filtered off
6. 6
   其他dried

实验过程

A mixture of 22 parts of 2-(4-methoxyphenyl)-1,3-dioxolane-2-methanamine hydrochloride, 11.5 parts of 1-isothiocyanato-2-methylpropane, 20.7 parts of potassium carbonate and 200 parts of 2-propanol is stirred and refluxed for 3 hours. The reaction mixture is filtered while hot and the filtrate is evaporated. The solid residue is crystallized from a mixture of benzene and petroleumether. The product is filtered off and dried, yielding 26 parts (89.65%) of N-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-N'-(2-methylpropyl)thiourea; mp. 96° C.

来源