反应 #57053

反应方程式

sodium carbonate

methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid

sulfuric acid

→

Methyl 1-(4-chlorophenyl)cyclobutanecarboxylate

溶剂

methanol

反应条件

后处理

1. 1
   温度The mixture was refluxed for overnight
2. 2
   其他The solvent was evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (50 mL)
4. 4
   洗涤washed with brine (3×10 mL)
5. 5
   干燥dried over MgSO4
6. 6
   其他The crude product was used for the next reaction without further purification

实验过程

To a solution of methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid (5.0 g, 23.73 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

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