反应 #569866

反应方程式

perhydrol

perhydrol

perhydrol

2-[2-(2,3-dimethylphenyl)-hydrazino]-2-thiazoline hydrochloride

sodium hydroxide

→

2-(2,3-dimethylphenylazo)-2-thiazoline

溶剂

methylene chloride

反应条件

后处理

1. 1
   温度under reflux
2. 2
   其他The organic phase was separated off
3. 3
   干燥dried over potassium carbonate
4. 4
   其他evaporated down
5. 5
   其他the residue was recrystallised from hexane/diethyl ether

实验过程

3.5 ml of 30% strength perhydrol were added to a mixture of 6.5 g (0.025 mol) of 2-[2-(2,3-dimethylphenyl)-hydrazino]-2-thiazoline hydrochloride, 60 ml of methylene chloride and 50 ml of 2N sodium hydroxide solution. The mixture was stirred for 18 hours under reflux, and a further 2 ml of perhydrol were added after 6 hours, and another 1 ml of perhydrol after 12 hours. The organic phase was separated off, dried over potassium carbonate and evaporated down, and the residue was recrystallised from hexane/diethyl ether. Mp. 74° to 79°, yield 4.1 g (74% of theory).

来源