反应 #569864

反应方程式

2-chloroethyl isothiocyanate

2,3-dimethylphenylhydrazine

→

2-[2-(2,3-dimethylphenyl)-hydrazino]-2-thiazoline

溶剂

toluene

toluene

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was further stirred for 2 hours at room temperature and for 2 hours
2. 2
   温度under reflux
3. 3
   过滤The product was filtered off with suction when cold
4. 4
   其他was recrystallised from isopropanol

实验过程

13.6 g (0.1 mol) of 2,3-dimethylphenylhydrazine were dissolved in 50 ml of toluene, and a solution of 12.8 (5% excess) of 2-chloroethyl isothiocyanate in 25 ml of toluene was added in the course of 15 minutes, while stirring and cooling with ice water, and the mixture was further stirred for 2 hours at room temperature and for 2 hours under reflux. The product was filtered off with suction when cold and was recrystallised from isopropanol. Mp. 220° to 221° (decomposition) (hydrochloride), 13.5 g (52.5% of theory).

来源