反应 #56590

反应方程式

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

收率 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

收率 82.5%

溶剂

dimethylsulfoxide

water

反应条件

后处理

1. 1
   其他to react for 4 days at 80° C
2. 2
   萃取extracted with ether
3. 3
   干燥The organic phase was then dried over sodium sulphate
4. 4
   过滤filtered
5. 5
   浓缩concentrated to dryness

实验过程

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

来源