反应 #56554

反应方程式

Lithium Borohydride

retinal

hydrochloric acid

→

beta-carotene

收率 60.0%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   其他A solution was prepared
2. 2
   温度the reaction was refluxed for four hours
3. 3
   萃取was extracted several times with ether
4. 4
   洗涤washed with saturated aqueous sodium chloride solution
5. 5
   干燥dried over magnesium sulfate
6. 6
   浓缩concentrated by solvent removal at the rotary evaporator
7. 7
   其他The residue was further purified by chromatography on silica gel
8. 8
   洗涤Elution with hexane

实验过程

A solution was prepared by dissolving titanium tetrachloride (1.10 ml, 10.0 mmol) in 25 ml dry tetrahydrofuran under an inert atmosphere. Lithium Borohydride (110 mg, 5.0 mmol) was added, and the resulting solution was stirred at 50° for two hours. A solution of retinal (1.42 gm, 5.0 mmol) 5 ml dry tetrahydrofuran was added, and the reaction was refluxed for four hours. After this, the solution was poured into 50 ml 2 N aqueous hydrochloric acid, and was extracted several times with ether. The ether extracts were combined, washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, and concentrated by solvent removal at the rotary evaporator. The residue was further purified by chromatography on silica gel. Elution with hexane gave 0.8 gm (60%) beta-carotene, identified by comparison with an authentic sample; mp 180°-182°.

来源