反应 #56536

反应方程式

α-n-octyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

benzyl triethylammonium hydroxide

→

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   萃取extracted with ether
3. 3
   洗涤The combined ether extracts are washed with water, saturated sodium chloride solution
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他The solvent is evaporated
6. 6
   其他to give 40 g

实验过程

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

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