反应 #5648

反应方程式

tribromide

1,3,5-trisbromomethyl benzene

nitronium tetrafluoroborate

water

→

nitro

收率 86.4%

2,4,6-Tris(bromomethyl)nitrobenzene

收率 86.4%

溶剂

CH3CN

CH3CN

反应条件

后处理

1. 1
   萃取the mixture extracted with CH2Cl2
2. 2
   洗涤The CH2Cl2 extracts were washed with 10% NaHCO3
3. 3
   干燥dried (Na2SO4) and solvents
4. 4
   其他removed

实验过程

To a solution of 5 g (0.014 mole) of the tribromide 8 in 100 ml of CH3CN was added, at room temperature and under argon atmosphere, in a dropwise fashion 3.72 g (0.028 mole) of nitronium tetrafluoroborate in 200 ml of CH3CN. The solution was then stirred for 20 minutes longer, poured into water and the mixture extracted with CH2Cl2. The CH2Cl2 extracts were washed with 10% NaHCO3, dried (Na2SO4) and solvents removed to afford 4.86 g (86%) of the desired nitro compound 27: NMR (CDCl3) 4.5 (s,6,--CH2Br), 7.55 (s,--C6H2).

来源