反应 #564353

反应方程式

5-cyano-2-thiophene carboxaldehyde

malonic acid

malonic acid

→

3-(5-Cyano-2-thiophenyl)-propenoic acid

溶剂

pyridine

piperidine

反应条件

后处理

1. 1
   温度under reflux for 2 hours
2. 2
   其他The solution was evaporated
3. 3
   其他to give a pale solid which
4. 4
   洗涤was washed with water
5. 5
   其他dried

实验过程

A stirred solution of 5-cyano-2-thiophene carboxaldehyde (3.3 g) and malonic acid (2.5 g) in pyridine (35 ml) and piperidine (0.7 ml) was heated under reflux for 2 hours adding further malonic acid (1.3 g) after 1 hour. The solution was evaporated and the residue was stirred with M hydrochloric acid solution (100 ml) to give a pale solid which was washed with water and dried, m.p. ca 260° C. (subliming).

来源