反应 #56383

ord-a88205c2903543be866b25bf4d868ba8

反应方程式

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C
beclomethasone dipropionate
ClCCl
methylene chloride
CC(C)=O
acetone
→
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C.CCCCCC
beclomethasone dipropionate n-hexane

反应物

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C
beclomethasone dipropionate
ClCCl
methylene chloride
CC(C)=O
acetone

试剂

无

溶剂

CCCCCC
n-hexane

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他The beclomethasone dipropionate-n-hexane solvate is prepared
  2. 2
    过滤The precipitate is filtered
  3. 3
    其他dried

实验过程

The beclomethasone dipropionate-n-hexane solvate is prepared by dissolving the beclomethasone dipropionate in a suitable organic solvent, such as methylene chloride or acetone, and then adding n-hexane to this solution resulting in the formation of a precipitate. The precipitate is filtered and dried to afford the beclomethasone dipropionate-n-hexane solvate.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US04225597uspto-grants-1980_09